Your position players are easy. You may make a change here and there during the week, but most of the time, you just set them and go. How you play your pitchers are a little different. There are maximums for innings pitched, so if you constantly rotate SPs in and out, you're going to hit your maximums before the end of the year, but some people decide to do that. Others will set their pitching rotation with 4-5 SPs and 2-3 closers and leave it.
All of this is up for changing if enough people don't want to play it that way.