Barry Sanders was a gifted runner, no doubt.
However, I'd submit Jan. 2nd, 1994 was the single greatest game by a running back. You know, when Emmitt had 168 rushing yards and 10 catches for 61 yds and a touchdown in the game that decided the division winner. With a separated shoulder.
More like a thoroughbred than a plow horse.
Edit: forgot my favorite part: Against the Giants. In New York.